Deus Ex: Human Revolution

IGN Preview

It has been a while since I needed to buy a new computer to play a game.

In addition to being a sequel to Deus Ex and looking generally bad-ass, transhumanism is explicitly mentioned. From the FAQ:

Essentially, DX: HR explores the beginnings of human augmentation and the transhumanism movement is a major influence in the game. There are people who think it's "playing God" to modify the body whatsoever and there are people (Transhumanists) who think it's the natural evolution of the human species to utilise technology. You're caught in the middle of this storm and must decide which path you take. The visual stigma augmentated people bear adds fuel to the huge societal rift between them and natural humans that's at the centre of Deus Ex: HR's vision of the future.