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Blueberry comments on Unknown knowns: Why did you choose to be monogamous? - Less Wrong
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Have you found pramipexole effective in reducing your refractory period? I hadn't realized there were drugs that could do that. I'm interested in trying: how much does it reduce your refractory period? What have your experiences been with it? It looks like there might be a lot of unpleasant side effects.
plus cross-dressing.
That is a seriously funny side effect. I presume it is just related to the boost in appeal of hedonistic activities and general drive towards anything. But still... cross dressing pills. :P
I would be extremely hesitant to recommend taking pramipexole just for the sexual side effects. It works as a powerful dopaminergic receptor agonist. You don't play recklessly with your dopamine system, it's not a toy... that's the acetylecholine system! ;) (Within reason!)
I have used pramipexole but I did so not (just) for the sexual effects but because the overall profile fit well with my needs at the time. I stopped using it because I found it made me work too hard, which has limits. It is also just like to cycle most substances that have stimulatory effects.
If I recall it was down to 5 minutes. It was absolutely ridiculous, especially when combined with cialis. I cannot speak for general applicability, studies have focussed on libido but I haven't seen anything except anecdotal evidence regarding refractory period affects.
Be careful and do your research.
Positive, but No Free Lunch. I recommend researching other people's experiences, with the Mind and Muscle and Immortality Institute forums being good places to start. The best thing about those forums is that they are absolutely riddled with citations from PubMed. That saves time tracking the solid evidence down!
Not as bad as with SSRIs but that says little. Want something that gives a mild libido boost but is also neuroprotective and an enhance motivation? Try selegiline. It is much less intrusive.
do you generally do DIY medicine? I was always leery of it, even if you do your research.
Absolutely.
To be clear my research involves consulting with professionals that I select for competence as well as qualification. This is too important to merely go with the flow.