= 27d567bc2d48d9f40e9ccc20ea370b15)
retiredurologist comments on Unknown knowns: Why did you choose to be monogamous? - Less Wrong
You are viewing a comment permalink. View the original post to see all comments and the full post content.
= 783df68a0f980790206b9ea87794c5b6)
Loading…= b715d02e85f7b3b4ae65ca3d3e450868)
Subscribe to RSS Feed
Powered by Reddit
= f037147d6e6c911a85753b9abdedda8d)
You are viewing a comment permalink. View the original post to see all comments and the full post content.
Comments (651)
" Yes, Pramipexole enhances libido for both sexes and in the case of males reduces or eliminates the refractory period."
If these effects were reproducibly demonstrable, controlling for placebo effect, Boehringer (it's maker) would be all over it with both feet, but they're not. They are the company that recently wasted many millions trying to get flibanserin approved for enhancing female libido. The FDA voted 10-1 that it was no better than placebo, and that the side effects were unacceptable. Boehringer would not likely have gone to all that trouble if they already had a FDA-approved drug (pramipexole) that they could have submitted for approval of a new indication without repeating all the pre-clinical safety trials.
You are mistaken. The maker tried to get FDA approval for this use but were unable to. I do not consider this particularly strong evidence that the effect is not present. Faith in the FDA as an efficient arbiter of truth is not a misconception that I suffer from.
I have very little evidence regarding whether that drug is effective. And yes, I am saying this after being informed of the FDA vote. I only consider a 10:1 vote against to be weak evidence in favor of the effectiveness of a drug for this particular application.
They did.
You may find it interesting to note that under the side effects of pramipexole the maker is required to list hypersexuality due to multiple studies showing increased sexual urges and 'hedonistic behavior'.
If it causes increased sexual urges in 1 in 100 people, it'll show up in studies but be useless to most people trying to increase their sexual urges.
Completely true.
Another interesting side effect of a medication, and one which can definitely not be relied upon, is inorgasmia. While SSRIs will almost always delay ejaculation (sometimes a good thing), in some cases they more or less prevent it entirely. This makes it possible to copulate until physical exhaustion:
TMI: Juvyr vg vfa'g zl hfhny rkcrevrapr gurer jnf bar jrrx va juvpu zl frkhny shapgvba erznvarq fgngvp ng n cbvag whfg orsber pbzcyrgvba. Guvf jnf fbzrguvat bs n abirygl fb n cnegare naq V qrpvqrq gb grfg gur yvzvgf bs bhe raqhenapr. Bhe erpbeq jnf 5 ubhef. V nz engure wrnybhf gung V qvq abg trg zl funer bs gur betnfzf!
Pharmacology is fun. :)
Fb lbh jrer arne betnfz sbe 5 ubhef? Gung'f nznmvat. Gung zhfg unir orra terng. Vg'f cbffvoyr gb fvzhyngr gung rssrpg ol punatvat fcrrqf naq fybjvat qbja qhevat frk ohg V'ir arire uryq bhg gung ybat. V'ir unq nabetnfzvp rssrpgf sebz FFEVf naq prageny areibhf flfgrz qrcerffnagf (Ivpbqva, nypbuby, nagvuvfgnzvarf, cbg) ohg vg'f nyjnlf orra bs gur glcr jurer V unir nyzbfg ab frafngvba, naq vg'f nyjnlf orra harawblnoyr naq sehfgengvat.
Arne betnfz. Ohg vg qvq inel. Vg jnf nf gubhtu vg xvaq bs nccebnpurq betnfz ohg gura qvrq onpx gb, lbh xabj, 'qrsnhyg frk fgngr', gura ohvyg hc... rgp.
Nf ybat nf lbh qba'g zvaq oyrrqvat sebz sevpgvba oheaf naq raqhevat rkgerzr zhfpyr sngvthr. Vg jnfa'g dhvgr nf rkunhfgvat nf jura V'ir eha znengubaf ohg vg jnf cerggl qnza pybfr. V guvax gur punyyratr jnf cebonoyl zber sha guna gur snpg gung vg jnf frk. Ohg V'z penml yvxr gung. :C
Lrnu, V pregnvayl pna'g ynfg 5 ubhef gung jnl. V oryvrir fbzr znyrf ner noyr gb genva gurzfryirf gb betnfz jvgubhg rwnphyngvat naq gurerol pbagvahr (naq betnfz ntnva) qhevat frk. Gurer vf fbzr qbhog gung rirelbar vf pncnoyr bs qbvat guvf rira haqre genvavat.
Um... that body part is not supposed to stay in that state for 5 hours. Maintaining an erection means diminished bloodflow to the area and anything over 4 hours calls for a trip to the emergency room.