wedrifid comments on Unknown knowns: Why did you choose to be monogamous? - Less Wrong

48 Post author: WrongBot 26 June 2010 02:50AM

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Comment author: wedrifid 29 June 2010 04:25:55AM 3 points [-]

I would be extremely hesitant to recommend taking pramipexole just for the sexual side effects. It works as a powerful dopaminergic receptor agonist. You don't play recklessly with your dopamine system, it's not a toy... that's the acetylecholine system! ;) (Within reason!)

I have used pramipexole but I did so not (just) for the sexual effects but because the overall profile fit well with my needs at the time. I stopped using it because I found it made me work too hard, which has limits. It is also just like to cycle most substances that have stimulatory effects.

Have you found pramipexole effective in reducing your refractory period? I hadn't realized there were drugs that could do that.

how much does it reduce your refractory period?

If I recall it was down to 5 minutes. It was absolutely ridiculous, especially when combined with cialis. I cannot speak for general applicability, studies have focussed on libido but I haven't seen anything except anecdotal evidence regarding refractory period affects.

I'm interested in trying

Be careful and do your research.

What have your experiences been with it?

Positive, but No Free Lunch. I recommend researching other people's experiences, with the Mind and Muscle and Immortality Institute forums being good places to start. The best thing about those forums is that they are absolutely riddled with citations from PubMed. That saves time tracking the solid evidence down!

It looks like there might be a lot of unpleasant side effects.

Not as bad as with SSRIs but that says little. Want something that gives a mild libido boost but is also neuroprotective and an enhance motivation? Try selegiline. It is much less intrusive.

Comment author: [deleted] 29 June 2010 04:41:38AM 1 point [-]

do you generally do DIY medicine? I was always leery of it, even if you do your research.

Comment author: wedrifid 29 June 2010 05:02:53AM 4 points [-]

do you generally do DIY medicine?

Absolutely.

I was always leery of it, even if you do your research.

To be clear my research involves consulting with professionals that I select for competence as well as qualification. This is too important to merely go with the flow.