So let me try to rewrite that (and don't be afraid to call this word salad):

(Note: the following comment is based on premises which are very probably completely unsound and unusually prone to bias. Read at your own caution and remember the distinction between impressions and beliefs. These are my impressions.)

You're Eliezer Yudkowsky. You live in a not-too-far-from-a-Singularity world, and a Singularity is a BIG event, decision theoretically and fun theoretically speaking. Isn't it odd that you find yourself at this time and place given all the people you could have found yourself as in your reference class? Isn't that unsettling? Now, if you look out at the stars and galaxies and seemingly infinite space (though you can't see that far), it looks as if the universe has been assigned measure via a universal prior (and not a speed prior) as it is algorithmically about as simple as you can get while still having life and yet seemingly very computationally expensive. And yet you find yourself as Eliezer Yudkowsky (staring at a personal computer, no less) in a close-to-Singularity world: surely some extra parameters must have been thrown into the description of this universe; surely your experience is not best described with a universal prior alone, instead of a universal prior plus some mixture of agents computing things according to their preference. In other words, this universe looks conspicuously like it has been optimized around Eliezer-does-something-multiversally-important. (I suppose this should also up your probability that you're a delusional narcissist, but there's not much to do about that.)

Now, if such optimization pressures exist, then one has to question some reductionist assumptions: if this universe gets at least some of its measure from the preferences of simulator-agents, then what features of the universe would be affected by those preferences? Computational cost is one. MWI implies a really big universe, and what are the chances that you would find yourself where you are in a really big universe as well as finding yourself in a conspicuously-optimized-seeming universe? Seemingly the two hypotheses are at odds. And what about cryonics? Do you really expect to die in a universe that seems to be optimized for having you around doing interesting things? (The answer to that could very well be yes, especially if your name is Light.) And when you have simulators in the picture, with explicit values, perhaps they have encoded rightness and wrongness into the fabric of reality via selectively pruning multiverse branches or something. Heaven knows what the gods do for fun.

These are of course ridiculous ideas, but ridiculous ideas that I am nonetheless hesitant to assign negligible probability to.

Maybe you're a lot less surprised to find yourself in this universe than I am, in which case none of my arguments apply. But I get the feeling that something is awfully odd is going on, and this makes me hesitant to be confident about some seemingly basic reductionist conclusions. Thus I advise you to buy a lottery ticket. It's the rational thing to do.

(Note: Although I personalized this for Eliezer, it applies to pretty much everyone to a greater or lesser degree. I remember (perhaps a secondhand and false memory, though, so don't take it too seriously) at some point Michael Vassar was really confused about why he didn't find himself as Eliezer Yudkowsky. I think the answer I would have thought up if I was him is that Michael Vassar is more decision theoretically multiversally important than Eliezer. Any other answer makes the question appear silly. Which it might be.)

(Alert to potential bias: I kinda like to be the contrarian-contrarian. Cryonics is dumb, MWI is wrong, buying a lottery ticket is a good idea, moral realism is a decent hypothesis, anthropic reasoning is more important than reductionist reasoning, CEV-like things won't ever work and are ridiculously easy to hack, TDT is unlikely to lead to any sort of game theoretic advantage and precommitments not to negotiate with blackmailers are fundamentally doomed, winning timeless war is more important than facilitating timeless trade, the Singularity is really near, religion is currently instrumentally rational for almost everyone, most altruists are actually egoists with relatively loose boundaries around identity, et cetera, et cetera.)