I guess I was reacting to your comparison of the "significant life change" experienced by the recipient and family/friends of a StopTB treatment and the "significant life change" that you would experience in losing $1000. The two are not comparable and the fact that you used the same phrase to describe them suggested to me that you were irrationally heavily minimizing the impact of a donation to StopTB on the recipients of the treatment.

I'm not saying that the fact that the two things are incomparable means that you ought to give. Again, see my post on altruism and sacrifice. I only ask that you make an honest assessment of what's being lost when you decline to donate.