The main problem in the discussion that appeared to me is the fact that the present state of the universe is really unlikely, and you would never get it by chance. This is true and the universe does naively appear to have been designed to produce us. However, this is a priori massively unlikely. This implies that we exist in a universe that tries out many possibilities (many worlds interpretation) and anthropic bias ensures that all observers see weird and interesting things. Robert's problem is that he gets an emotion kick out of ascribing human-friendly purpose to survivorship bias. I'm pretty sure that nothing other than the most painstaking argument is going to get him to realize his folly, and that just isn't going to happen in one hour video chats.
The main problem in the discussion that appeared to me is the fact that the present state of the universe is really unlikely, and you would never get it by chance.
Any hypothesis that assigns a really low probability to the present state of the universe is probably wrong.
Sweet, there's another Bloggingheads episode with Eliezer.
Bloggingheads: Robert Wright and Eliezer Yudkowsky: Science Saturday: Purposes and Futures