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ocr-fork comments on Open Thread, August 2010-- part 2 - Less Wrong
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Off the top of my head:
The laws of physics
9 months in the womb
The rest of your organs. (maybe)
Your entire childhood...
These are barriers developing Kurzweil's simulator in the first place, NOT to implementing it in as few lines of code as possible. A brain simulating machine might easily fit in a million lines of code, and it could be written by 2020 if the singularity happens first, but not by involving actual proteins . That's idiotic.