In the year 2020, cousin_it downloads some software for running predictor sims. He wants to optimize his future conduct -test which particular minor mind-hack would be the most beneficial, given his individual psychological makeup. So he runs many ancestor sims of himself poisoned with different irrational mind-hacks to see who wins in the past. I am one such sim, poisoned in an unknown manner; what should I do?

I have precommitted as strongly as I can to never run simulations of myself which are worse off than the version the simulation was based on. This might fall out as a consequence of UDT, but with a time-varying utility function I'm not really sure.

In general, self-copying and self-simulation require extreme care. They might be able to affect subjective experience in a way that goes back in time. The rules of subjective experience, if any, are non-transferrable (you can't learn them from someone else who's figured them out, even in principle) and might not be discoverable at all.