NancyLebovitz comments on Taking Ideas Seriously - Less Wrong
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I believe it's false. Good-sized animals are still being discovered. The ecology of micro-organisms is still being explored.
A lot of what's worth finding out at our present level of knowledge isn't about whole organisms, it's about specific aspects-- consider the work being done with spider silk. Spider silk would probably still be valuable even if there weren't any living spiders.
On the small side, but pea-sized frog recently discovered.