I think in many types of game there's an implicit convention that they're only going to be fun if you follow the obvious strategies on auto-pilot and don't optimize too much or try to behave in ways that would make sense in the real world, and breaking this convention without explicitly labeling the game as competitive or a rationality test will mostly just be annoying.
The idea of having a game resemble real-world science is a good one and not one that as far as I know has ever been done anywhere near as well as seems possible.
Good point. I guess the game's labeling system shouldn't deceive you like that, but it would need to have characters that promote non-functioning technology, after some warning that e.g. not everyone is reliable, that these people aren't the tutorial.
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