Riffing off my weird biology / chemistry thing: a game based on the breeding of weird creatures, by humans freshly arrived on the planet (add some dimensional travel if you want to justify weird chemistry - I'm thinking of Tryslmaistan.

The catch is (spoiler warning!), the humans got the wrong rules for creature breeding, and some plantcrystalthingy they think is the creatures' food is actually part of their reproduction cycle, where some essential "genetic" information passes.

And most of the things that look like in-game help and tutorials are actually wrong, and based on a model that's more complicated than the real one (it's just a model that's closer to earth biology).