pjeby comments on A "Failure to Evaluate Return-on-Time" Fallacy - Less Wrong
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I agree, I don't think these kind of 'easy' wins are all that common in real life, certainly not those offering 300x improvements. I would like to see some better examples.
Entrepreneurship / business seems likely to be relatively fertile ground for finding good examples since short term financial gain can often be used as a relatively good proxy for 'success' and is relatively easy to measure. Too much focus on short term financial gain isn't always an optimal strategy even in business however since it may result in getting stuck in local maxima or directly compromising longer term success.
That depends on the universe out of which you're selecting/counting them. In business, most attempts to improve things have zero (or very nearly zero) positive effect on the bottom line, and thus finding things that are 300x or more better than the worst case or even typical case isn't really that hard. ;-)
Understanding constraints and the Pareto Principle are critical to making effective improvements in business, i.e., ones that have non-zero chances of affecting the bottom line.