The fact that you will regret a choice does not imply that the choice is irrational, since the way our regret works is itself irrational.

If we accept Eliezer's position, we'd probably take all of these things - pleasure, non-effort, non-regret, happiness, etc. - and make them components of our utility functions. But I have no idea how we are supposed to weigh these things against each other. How do you know that your consciously chosen trade-off is the right one? How do you even know that it's an improvement over what your subconscious/instinct/intuition tends to choose?