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AndrewHickey comments on Intelligence Amplification Open Thread - Less Wrong
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I've had really good success with 5HTP. It begins working in your desired time frame, and has consistently make me calmer, more focused, and more positive.
Piracetam and sulbutiamine didn't seem to do anything for me though.
I'd be VERY careful with 5-HTP . Very careful indeed. I used it for a couple of years and it had some beneficial effects (increased sleep, decreased migraine, decreased depression, general cognitive improvement). But anything that affects your serotonergetic system can have nasty unpredictable effects. In my case, I upped my caffeine intake a lot, without realising that caffeine can have a synergetic effect with 5-HTP, and gave myself mild <a href="http://en.wikipedia.org/wiki/Serotonin_syndrome">serotonin syndrome</a>. NOT pleasant. In particular, if you take any kind of SSRI, don't touch 5-HTP with a bargepole...