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AndrewHickey comments on Intelligence Amplification Open Thread - Less Wrong
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My own experience was that 5-HTP had a VERY noticeable effect on my sleep for the first week or two, after which point I built up a tolerance to it in that respect at least. I switched to melatonin after the problems I mentioned above, and that had a much less noticeable effect, but the effect didn't taper off at all as it did with 5-HTP...