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Vladimir_Nesov comments on Strategies for dealing with emotional nihilism - Less Wrong
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Are we talking about nihilism here or depression?
Nihilism is a philosophical position.
Depression is a mood - a physiological state which causes a psychological state.
Nihilism is sometimes offered by depressed people as a rationalization/justification of their behavior. It is an effect, not a cause.
Chronic depression can be treated pharmaceutically. Episodes of depression often respond to physical activity. Running is a good suggestion for some people.
Nihilism, as a philosophical position, can be treated by reading better philosophy. However, treating nihilism does nothing to cure depression.
I expect to an extent one can establish behavior despite shifts in psychological drives, if there is something to protect and honest non-compartmentalized philosophical position says you ought to perform certain actions, even if you don't feel adequately driven (or passive drives strive to overpower).