I'm not talking about philosophical nihilism. I'm talking about a kind of psychological state: lack of motivation, lack of pleasure and desire, temptation to give up on everything. It's the sense that very little matters.

I didn't want to call it "depression" because I didn't want to deal with the issue of whether this is a part of normal life or a pathology -- I thought I would describe the psychological state itself, and taboo the name for it. I actually don't know when and for whom pharmacological solutions are appropriate. That's something I'd like to understand better.