6) A drug which puts you in the state of asking "does what I'm doing make sense?", doing an honest search for an answer., and then putting the answer into effect.
Admittedly, the drug that gives you a pony would be easier, but I think that reflectiveness and executive function have physical bases.
I find that marijuana makes me MUCH more internally honest by suppressing flinch responses. YMMV. (Unsurprisingly, it doesn't help with putting things into effect, but the insight remains, as does the sense of what it's like to be / alief that I can survive being honest. I have heard good things about weed + Adderall, but never tried it.)
We operate like this: the "overseer process" tells the brain, using blunt instruments like chemicals, that we need to find something to eat, somewhere to sleep or someone to mate with. Then the brain follows orders. Unfortunately the orders we receive from the "overseer" are often wrong, even though they were right in the ancestral environment. It seems the easiest way to improve humans isn't to augment their brains - it's to send them better orders, e.g. using drugs. Here's a list of fantasy brain-affecting drugs that I would find useful, even though they don't seem to do anything complicated except affecting "overseer" chemistry:
1) A drug against unrequited love, aka "infatuation" or 'limerence".
2) A drug that makes you become restless and want to exercise.
3) A drug that puts you in the state of random creativity that you normally experience just before falling asleep.
4) A drug that puts you in the optimal PUA "state".
5) A drug that boosts your feeling of curiosity. Must be great for doing math or science.
Anything else?