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NancyLebovitz comments on In which I fantasize about drugs - Less Wrong
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6) A drug which puts you in the state of asking "does what I'm doing make sense?", doing an honest search for an answer., and then putting the answer into effect.
Admittedly, the drug that gives you a pony would be easier, but I think that reflectiveness and executive function have physical bases.
I find that marijuana makes me MUCH more internally honest by suppressing flinch responses. YMMV. (Unsurprisingly, it doesn't help with putting things into effect, but the insight remains, as does the feeling of what it's like to be / alief that I can survive being honest.)