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Kevin comments on In which I fantasize about drugs - Less Wrong

11 Post author: cousin_it 12 October 2010 04:19PM

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Comment author: Kevin 12 October 2010 11:26:26PM *  8 points [-]

1) Antidepressants

2) Amphetamine/methylphenidate (though it's not a pure reinforcement of wanting to excercise)

3) High doses of melatonin (3mg at least, stronger effects at 10mg+) and then staying awake. Also cannabis, or audio/visual brainwave entrainment.

4) I had a kratom customer that was a professional PUA (meaning clients paid him for applied lessons) and he found kratom before hitting the clubs helpful for him and his clients.

5) Cannabis. But it's not really great for doing math or science...

Comment author: gensym 13 October 2010 03:54:45AM *  3 points [-]

Seconding methylphenidate for #2, and (specifically) delta-wave-inducing binaural beats for #3.

I've heard good things about weed + Adderall for creative production, but never tried it.

Comment author: Risto_Saarelma 15 October 2010 11:16:06AM 1 point [-]

delta-wave-inducing binaural beats for #3

Do you know of any way of figuring out if binaural beats actually have a stronger effect than just listening to random ambient noise? The idea's cute, but last I looked at it, there wasn't much research confirming the brainwave entrainment effect.

Comment author: gensym 08 December 2010 06:40:20AM *  2 points [-]

A binaural beat converted to mono sounds like a good control. I do plan to test this sometime soon.

Comment author: Kevin 08 December 2010 07:52:37AM 1 point [-]
Comment author: Risto_Saarelma 08 December 2010 10:54:32AM 0 points [-]

That is interesting, thanks.

So it looks like a bit inconclusive for now. One publication reported an effect, the other study didn't find anything.

Comment author: Kevin 08 December 2010 11:16:15AM 0 points [-]

The studies were of different things... sorry, I thought I was linking to a study and replication. Binaural beats don't replace propofol for the induction of anesthesia, but they can help lower the heart rate in such a way that less fentanyl is needed to maintain heard rate/blood pressure within norms of baseline.

The replication of this study found the same effect, though not quite as strongly.

Comment author: kodos96 31 December 2012 03:56:56AM 0 points [-]

delta-wave-inducing binaural beats

Do you have any recommendations for a currently commercially available (or freely available) source of binaural beats? I experimented with a binaural beat "mind machine" years ago, and saw no significant results, but still find the idea fascinating.

Comment author: Risto_Saarelma 02 January 2013 12:04:13PM 2 points [-]

SBaGen is free software, and should come with various waveform scripts you can experiment with.

I don't know of any recommendations for a particular binaural track or waveform parameter set that would have been somehow verified to cause a specific mental response better than other types of tracks.

Comment author: yli 02 January 2013 01:19:11PM *  1 point [-]

I'd love to see some blind testing of this brainwave stuff to see whether it's more than placebo.

Doesn't seem too hard to do. Just do a blind comparison of genuine binaural beats carefully crafted to induce a state of concentration or whatever, and random noise or misadjusted binaural beats. It probably requires two people though, the tester and someone other than the tester to create the audio files and give them to the tester without telling them which is which. The tester should preferably be a binaural beats virgin - they should never have heard binaural beats before.

Something along the lines of the above would probably work, but I haven't thought about the experimental protocol in detail. If someone actually goes ahead with this, obviously they're gonna have to flesh it out and agree on a more precise protocol.

Personally, I couldn't be the tester because I've listened to binaural beats before and might recognize them. I might be able to be the fake audio file creator, but I'd have to look into it more to make sure I can create something that doesn't accidentally have binaural beats in it, etc.

Comment author: John_Maxwell_IV 16 October 2012 09:37:12PM 0 points [-]

I had a kratom customer that was a professional PUA (meaning clients paid him for applied lessons) and he found kratom before hitting the clubs helpful for him and his clients.

Does kratom mix well with alcohol?

Comment author: cousin_it 13 October 2010 04:23:57AM 0 points [-]

A kratom customer? Wait, are you that guy who sold kratom on reddit back in the day?

Comment author: Kevin 13 October 2010 08:11:42AM 2 points [-]

You're probably thinking of Hacker News. And yes, my two epic flamewar threads on HN seem to have been very memorable to people three years down the road.