In my experience, Modafinil is great at inducing exercise desire. I also find I'm more creative on Modafinil as well. The best thing though, by far, is how dramatically it improves my social ability, talkativeness, and general social adeptness. I took it before a high-stress, two-hour long, panel-style job interview, and I had the single best two hours of social performance of my life. It is, by far, the most generally positive drug I've ever tried. I take it about 3-4 times a week. It also seems to have corrected my insomnia, strangely enough.
We operate like this: the "overseer process" tells the brain, using blunt instruments like chemicals, that we need to find something to eat, somewhere to sleep or someone to mate with. Then the brain follows orders. Unfortunately the orders we receive from the "overseer" are often wrong, even though they were right in the ancestral environment. It seems the easiest way to improve humans isn't to augment their brains - it's to send them better orders, e.g. using drugs. Here's a list of fantasy brain-affecting drugs that I would find useful, even though they don't seem to do anything complicated except affecting "overseer" chemistry:
1) A drug against unrequited love, aka "infatuation" or 'limerence".
2) A drug that makes you become restless and want to exercise.
3) A drug that puts you in the state of random creativity that you normally experience just before falling asleep.
4) A drug that puts you in the optimal PUA "state".
5) A drug that boosts your feeling of curiosity. Must be great for doing math or science.
Anything else?