Yes, but you'll still have to change the page size and recompile each of the 600 or so PDFs -- this is a huge amount of work if you're planning to do it manually. Generating PDFs for different screen sizes automatically (e.g. using a Python library) would be a better solution. I'm not familiar with PDF generation under Python, but I did a quick Google search and here's what I found:

http://www.devshed.com/c/a/Python/Python-for-PDF-Generation/
http://www.reportlab.com/software/opensource/