I've thought of this from the angle of the Fermi paradox. Afaik, Fermi thought war was a major filter. Spam is a minor indicator that individual sociopathy could be another filter as individual power increases. How far are we from home build-a-virus kits?
The major hope [1] I can see is that any of the nano or bio tech which could be used to destroy the human race will have a run-up period, and there will be nano and bio immune systems which might be good enough that the human race won't be at risk, even though there may be large disasters.
[1]Computer programs seem much more able to self-optimize than nano and bio systems. Except that of course, a self-optimizing AI would use nano and bio methods if they seem appropriate.
This is not a cheering thought. I think the only reasonably popular ideology which poses a major risk is the "humanity is a cancer on the planet" sort of enviromentalism-- it seems plausible that a merely pretty good self-optimizing AI tasked with eliminating the human race for the sake of other living creatures would be a lot easier to build than an FAI, and it might be possible to pull a group of people together to work on it.
I'd also be worried about:
depressed microbiologists
religious fanatics who have too much trust that 'God will protect them' from their virus
Buddhists who loose their memetic immune system and start taking the 'material existence is inherently undesirable' aspect of their religion seriously, or for that mater a practitioner of an Abrahamic religion who takes the idea of heaven seriously.