Danny_Hintze comments on Best career models for doing research? - Less Wrong
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I believe that most people hoping to do independent academic research vastly underestimate both the amount of prior work done in their field of interest, and the advantages of working with other very smart and knowledgeable people. Note that it isn't just about working with other people, but with other very smart people. That is, there is a difference between "working at a university / research institute" and "working at a top university / research institute". (For instance, if you want to do AI research in the U.S., you probably want to be at MIT, Princeton, Carnegie Mellon, Stanford, CalTech, or UC Berkeley. I don't know about other countries.)
Unfortunately, my general impression is that most people on LessWrong are mostly unaware of the progress made in statistical machine learning (presumably the brand of AI that most LWers care about) and cognitive science in the last 20 years (I mention these two fields because I assume they are the most popular on LW, and also because I know the most about them). And I'm not talking about impressive-looking results that dodge around the real issues, I'm talking about fundamental progress towards resolving the key problems in artificial intelligence. Anyone planning to do AI research should probably at least understand these first, and what the remaining obstacles are.
You aren't going to understand this without doing a lot of reading, and by the time you've done that reading, you'll probably have identified a research group whose work clearly reflects your personal research goals. At this point it seems like the obvious next step is to apply to work with that group as a graduate student / post doc. This circumvents the problem of having to work on research you aren't interested in. As for other annoyances, while teaching can potentially be a time-sink, the rest of "wasted" time seems to be about publishing your work; I really find it hard to justify not publishing your work, since (a) other people need to know about it, and (b) writing up your results formally oftentimes leads to a noticeably deeper understanding than otherwise. Of course, you can waste time trying to make your results look better than they are, but this certainly isn't a requirement and has obvious ethical issues.
EDIT: There is the eventual problem that senior professors spend more and more of their time on administrative work / providing guidance to their lab, rather than doing research themselves. But this isn't going to be an issue until you get tenure, which is, if you do a post-doc, something like 10-15 years out from starting graduate school.
This might not even be a significant problem when the time does come around. High fluid intelligence only lasts for so long, and thus using more crystallized intelligence later on in life to guide research efforts rather than directly performing research yourself is not a bad strategy if the goal is to optimize for the actual research results.
Those are roughly my thoughts as well, although I'm afraid that I only believe this to rationalize my decision to go into academia. While the argument makes sense, there are definitely professors that express frustration with their position.
What does seem like pretty sound logic is that if you could get better results without a research group, you wouldn't form a research group. So you probably won't run into the problem of achieving suboptimal results from administrative overhead (you could always just hire less people), but you might run into the problem of doing work that is less fun than it could be.
Another point is that plausibly some other profession (corporate work?) would have less administrative overhead per unit of efficiency, but I don't actually believe this to be true.