novalis comments on Efficient Charity: Do Unto Others... - Less Wrong
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There is one exception to this, which is political charities (ACLU, for instance). Giving to political charities, has a signalling effect: a political charity can say "we have twelve million donors," and this tells politicians that they had better listen to that charity or those twelve million people might be voting for someone else.
That said, a $10 donation is enough to get this effect.