Science before the mid-20th century was too small to look like a target.
In this case I interpreted it to mean that there are many people now who specifically target science as bad (i.e. complain about "scientism" etc.) because science is a large, successful enterprise. He is asserting that before the mid 20th century science was not prominent or successful enough to bother being a target of attack. I'm not sure he's correct here, but the basic notion is plausible.
Ah, I see. I was thinking "small target in a large search space" kind of target. Thanks.
Will Newsome has suggested that I repost my tweets to LessWrong. With some trepidation, and after going through my tweets and categorizing them, I picked the ones that seemed the most rationality-oriented. I held some in reserve to keep the post short; those could be posted later in a separate post or in the comments here. I'd be happy to expand on anything here that requires clarity.
Epistemology
Group Epistemology
Learning
Instrumental Rationality