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Molybdenumblue comments on Rationality Quotes: January 2011 - Less Wrong
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What makes you think this (your second sentence) is not the case? Plenty of devastating diseases still cannot be prevented by vaccines; that's why people continue to research and create new ones.
Whether all publicly available vaccines (or, more weakly but more relevantly, all recommended vaccines for a particular individual) are worth getting is a separate question, but the recommendations are evidence-based, and I personally believe they represent a guess as good as I can make.
Which doesn't imply overwhelming evidence, though. Just enough evidence.
Agreed; I probably wouldn't have said "overwhelming evidence". But I do think there are still large gains to be made by vaccinating against more diseases, like, say, strep.
Revelation: The point of diminishing returns we would (in an ideal reach) is where health benefits are proportional to research dollars. Once a vaccine is researched, health benefits should be positive. However, variation, like the variation between regions, means that there are cases where an established vaccine has no benefits.