How to Win Friends and Influence People is a good book for general social skills, but it just doesn't sufficiently cover sociosexual dynamics, particular gender-specific behavior and preferences. It's like taking an excellent algebra book to your trig class.

The book is unlikely to substitute for pickup, though it could be a complement, and some PUAs do read it. We should never expect gender-neutral advice to be sufficient for those who have difficulty attracting the other gender or understanding their psychology.