Since one of the more common criticisms of the PUA scene is that it perpetuates an oversimplified view of relationships wherein women respond exclusively to deterministic social signals, that analogy's not going to win you much goodwill.

No more so than arguments for women using makeup or getting plastic surgery. Do these assume men respond exclusively to a woman's looks? Not really. It just says, do this, and more and better men will want you than before. Maybe other factors matter, maybe they don't, but this works, on top of whatever else might work. To the extent that PUA is offensive for insinuating women only care about a few metrics, so too are beauty products offensive.

There is a lot of PUA technique that amounts to an artificial means of improving unconscious or semi-conscious social signaling, and that strikes me as fairly inoffensive, but unless I'm one-minding badly here I don't think that part of the culture is a common target of criticism.

I'm afraid it is part of the criticism: people have this belief that social interaction should just come naturally and people shouldn't build models of it to understand it better -- so if you're a non-neurotypical, high IQ male, tough, you "deserve what you get", and any scientific approach to social interaction that is helpful to such undeserving males constitutes terrorism.