My objection is purely based on the side effects I've experienced, and I've only been on a limited number of drugs. Every mood stabilizer that I've been on has left me intellectually and emotionally crippled. That is perhaps putting it too strongly, but when I stopped the last drug I was on, my internal reaction was "Oh. This is what it's like to be alive. I had forgotten." The really upsetting thing was that I had slowly faded (cognitively) to where I didn't even notice that I was impaired, even though I had stopped getting work done and stopped participating in relationships. I was a pre-op Algernon (or Charlie, I guess), and that's not a person I'm willing to be.
I haven't actually taken lithium. I believe it's not as useful for treating depression, which is my real problem, but it's probably a bad idea for me to have around anyway; psychiatrists avoid prescribing it to patients who have a history of suicidal tendencies, because it is so toxic that it is occasionally used by those patients in suicide attempts.
Related to: Akrasia as a collective action problem and Self-empathy as a source of "willpower".
The Less Wrong community has discussed negotiating with one's conflicting sub-agents as a method to defeat akrasia and other forms of dynamic inconsistency, with some mix of reactions about how possible or effective that strategy can be. This article presents a successful example in my life, though it is probably an extreme outlier for a number of reasons.
I have been diagnosed with bipolar II disorder. It is one of the most significant challenges in my life, and certainly the one with the most dire implications. I can be fairly well modeled as three major sub-agents1:
Neutral feels it necessary to let Hypomanic take control more often to ensure that the compromise has weight to Depressed, but has started using Hypomanic to accomplish goals that are otherwise too exhausting to attain (a several-day code crunch or a need to meet and make a good impression on dozens of people). Meanwhile, Hypomanic has been more responsible lately in relinquishing control within days rather than weeks, partially because of these negotiations, but mostly because of other people in my life who have been conscripted to help monitor and rein me in.
I do not have a great deal of proven success with this strategy. I started doing this less than a year ago, and have not dealt with a full-blown major depressive episode since then. During that time I have also been more successful than ever at preventing myself from slipping into depression in the first place and treating early depression aggressively. In the end, that makes a much more significant difference, but on the two occasions when I became depressed enough to start feeling suicidal I was positively influenced by this agreement.
It seems unlikely that this approach will help many people with anything, but I feel like it is interesting in the debate about dynamic inconsistency, and I encourage others to find mutually-beneficial agreements they can make with themselves if they also feel like they deal with mutually incompatible agents from time to time. Also, this is my first post that is more than a link, so please be constructive.
Notes
1 I've never used names to refer to myself in different states, and don't think of my major sub-agents as individuals, but I felt that it was useful for didactic purposes to refer to myself in different states as different proper nouns.
2 I don't race cars, do drugs, or get in fights (except at the dojo). I do push my physical limits farther than I should (do parkour that I'm not be ready for, run 20km when I usually run 5, etc.), and I have injured myself this way, but just pulled muscles, sprains and once a broken finger.
3 I haven't heard this argument before, but this is the reason I haven't signed up for cryonics.
If it's not obvious, I was in a neutral state when I wrote this. It would have been impossible for me to do while depressed, and unlikely for me to try while hypomanic. I tried to de-bias myself, but no matter what state I'm in, I prefer my own viewpoint, and speak less highly of the others that diverge.