I know of a philosopher who claimed to have finished a grand theory he was working on, concluded that all life was meaningless, and thus withdrew from society and lived on a boat for many years fishing to live and practicing lucid dreaming. His doctrine was that we can't control reality, so we might as well withdraw to dreams, where complete control can be exercised by the trained.

I also remember reading about a philosopher who finished some sort of ultra-nihilist theory, concluded that life was indeed completely meaningless, and committed suicide-- getting wound up too tightly in a theory can be hazardous to your physical as well as epistemic health!