Skatche comments on A rationalist's guide to psychoactive drugs - Less Wrong

59 Post author: Skatche 10 February 2011 01:01AM

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Comment author: Skatche 11 February 2011 01:48:25AM -1 points [-]

Thanks for the heads up; has this happened to you? What did you take, and were you on anything else at the time?

Comment author: [deleted] 11 February 2011 08:50:23AM 0 points [-]

I believe so - I was never officially diagnosed, but became extremely ill and became better pretty much instantly on withdrawal of the 5-HTP. The symptoms matched those of serotonin syndrome, so I believe I had it - if I did, I was very lucky, as it can be fatal. I was taking, at the time, two over-the-counter 5-HTP supplements per day (can't remember the dosage, but they were fairly standard ones), but I was combining it with a lot of coffee - maybe ten, fifteen cups a day? - and that can have a synergetic effect when combined with serotonin precursors, as caffeine acts on the serotonergetic system.

Comment author: wedrifid 11 February 2011 09:50:19AM -1 points [-]

That is a lot of caffeine! Are you still on that much?

Comment author: [deleted] 11 February 2011 11:27:47AM 0 points [-]

No - at the time I was being paid by the hour, and not a very high wage, so I was working 13-and-a-half hour days. These days I limit myself to four cups a day maximum (three at weekends) and I don't take any 5-HTP (I do take melatonin though).