Overall, I think more people should be encouraged to pursue quotidian careers in areas that actually build tangible wealth, like construction, manufacturing, import/export, and traditional business (i.e. not dot-com or biotech).

If [you are independently wealthy], you should think more about careers in low-paying areas like mathematics, physics, literature, or art.

Right now I actually believe that smart people doing foundational work in biotechnology and synthetic biology are creating wealth at a greater rate than almost anyone else in society, though this is an essentially factual question about which we could argue.

I don't think independently wealthy people should go into mathematics, physics, literature, or art. I would be strongly tempted to go into mathematics, physics, or theoretical computer science if I weren't independently wealthy, since I'm basically completely confident I can make a comfortable living in any of those fields. Having money allows you to do riskier things, or things for which society might not compensate you at all.