JGWeissman comments on Is GiveWell.org the best charity (excluding SIAI)? - Less Wrong
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It seems that knowing if and to what extent a charity helps people become productive participants in the economy would be valuable to you. As near as I can tell, GiveWell does not rate charities on this criteria. As it sounds like you are planning to donate a substantial amount, you should consider contacting them about making an earmarked donation (I don't know if they actually do this, but it is worth trying) for a research project to establish such ratings.
GiveWell has an economic empowerment category, but says that the efficacy and transparency of interventions and charities in that sector are too poor to recommend anything in the category in comparison with public health.