MinibearRex comments on Rationality Quotes: March 2011 - Less Wrong
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"The greatest obstacle to discovery is not ignorance - it is the illusion of knowledge." -Daniel J. Boorstin
This reminds me of "It ain't what we don't know that hurts us, it's what we know that ain't so."
Which I have seen attributed to at least half a dozen different people over the years.
Also, "what we don't know that we don't know"