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sketerpot comments on Rationality Quotes: March 2011 - Less Wrong
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That's a tricky thing to specialize in. Got any ideas about how someone would go about it?
If you interpret "impossible" as meaning "things a lot of people call impossible", then the obvious method would be to make a list of such things, research them to see if there are any where you have a plausible chance of making a difference, and figure out which of them you'd prefer to specialize in.