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NancyLebovitz comments on How I Lost 100 Pounds Using TDT - Less Wrong
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To generalize a bit: I believe that people's bodies make choices about what to do when handed some calories-- the calories are allocated to heat, movement, immune system, fat, thinking, etc., and very little is known about how to affect how calories are allocated. Treatment for thyroid problems can help, I think-- if that happens to be your problem and your doctor is more astute than most.
One thing that presumably massively influences calory-allocation may be the the prevalence of brown fat in some adult humans. I found a lot of unusual observations about my (privileged) metabolism suddenly explained by the presumed presence of it. See http://en.wikipedia.org/wiki/Brown_adipose_tissue#Presence_in_adults
There are some biases that make me favouring this explanation, and there is contradicting evidence, so I am not so sure anymore.