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SarahC comments on How I Lost 100 Pounds Using TDT - Less Wrong
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Bleah. Still not used to this high status thing.
But seriously, if you are not metabolically privileged, what happens if you try this is that your body shuts down and goes into starvation mode instead of losing weight. Your fat cells do not release fat under any circumstances, though they're happy to hoover up blood sugar so you always feel tired. We're not talking "feeling hungry", we're talking that you stop feeling hungry and lie down, feeling very very cold and having a hard time moving. Literal starvation, instead of your fat cells releasing fat. I've never tried starving myself that much (I worry that it will cause my brain to cannibalize irreplaceable neurons or something, the way the rest of the body cannibalizes muscle) but I've just recently watched that happen to someone else who tried to lose weight by not eating and wasn't metabolically privileged enough to get away with it.
A calorie is not a calorie. The thermodynamic theory of metabolism is a fucking lie. And it seriously does wear away on your nerves like sandpaper, after a while, to be blamed for it, when the exact same diet can make one person thin and cause the other to blow up like a balloon...
Eh, just read "Beware of Other-Optimizing."
I'm convinced that this is a science that doesn't exist yet. (Or, at least, isn't established yet.) Sharing information anecdotally is better than not sharing it, but we haven't worked out the principles yet.
I've experienced "starvation mode" and I'm sure as hell not interested in eating that little for any longer than a day or two. I think (with low confidence, though I've seen some physiological just-so stories) that things like exercise and macronutrient breakdown affect whether or not you go into "starvation mode" on a given number of calories. But, regardless, it sucks and people are quite sensible to avoid doing things to their bodies that make them feel like dead dogs.
Edit: I am not a doctor, but the other standard thing to get checked is testosterone levels.