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Kaj_Sotala comments on How to Be Happy - Less Wrong
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Based on The Happiness Hypothesis, there are three things that have been shown to increase your tolerance for setbacks: meditation, cognitive behavioral therapy, and Prozac. All three help you take negative things less seriously.
(Better references upcoming once I my friend returns my copy of the book to me. Or someone else who has it can give the cites to the relevant research.)
My tolerance for setbacks can be increased dramatically by knowing how to fix it.
That sounds about right, though having supportive intimate relationships will also increase tolerance for setbacks. That recommendation, as well as meditation, therapy, and pills, are given in the original post.