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Eugine_Nier comments on A few minor comparisons of the results of Genetic egineering and Natural selection - Less Wrong
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Once the number and quality of your offspring is based on your wealth and access to the latest biotech as opposed to your sexual partner(s), sexual selection becomes a lot weaker.
This is a very important point. Especially the development of the artificial uterus or a libertarian approach to surrogacy would change the game immensely.