As one self-contained point (which doesn't bear most of my intuition, isn't strong in itself), I don't see how finer details about the way brain actually works (e.g. roles of pleasure/desire) can be important for this question. The fact that this is apparently going to be important in the planned sequence tells me that it'll probably go in a wrong direction. Similarly, emphasis on science, where the sheer load of empirical facts can distract from the way they should be interpreted.