General discussion, especially on instrumental rationality and improving one's effectiveness. I'm somewhat less interested in discussing particular sequences, but I don't have enough confidence in my mental model of such a discussion to feel like I can make a very good estimate. I don't live anywhere near a meetup, so I see this as a way to have general contact with other LWers as well.

Edit: Weekday evenings (T/W/Th) are okay for me, but sometime on the weekend in the afternoon or evening is best.