A human brain is a computer. The brain of a living human differs from a dead one in that it's running a program. If the universe is as it seems, running a program on a computer causes qualia.

If the simulation hypothesis is true, human brains are still programs; they're just running on different computers.

Unless you have some reason qualia would be more likely to occur when the program is run on one of those computers than the other, you have no evidence about the simulation hypothesis.