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Peterdjones comments on Three consistent positions for computationalists - Less Wrong
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The very premise of "Mary is supposed to have that kind of knowledge" implies that her brain is already in the requisite configuration that the surgery would produce. But if it's not already in that configuration, she's not going to be able to get it into that configuration just by looking at the right sequence of squiggles on paper. All knowledge can be represented by a bunch of 1's and 0's, and Mary can interpret those 1's and 0's as a HOWTO for a surgical procedure. But the knowledge itself consists of a certain configuration of neurons, not 1's and 0's.
No, the premise of the Mary argument is that Mary has all possible book-larnin' or third person knowledge. She is specifically not supposed to be pre-equipped with experiential knowledge, which means her brain is in one of the physical states of a brain that has never seen colour.
No, she is not going to be able to instantiate a red quale through her book learning: that is not what is at issue. What is at issue is why she would need to.
Third person knowledge does not essentially change on translation from book to paper to CD, and for that matter it should not essentially change when loaded into a brain. And in most cases, we think it doesn't. We don't think that the knowledge of photosyhtesis means photsynthesising in your head. You share that the qualiaphobes assumption that there is something special about knowledge of qualia that requires instantiation.
Well, then when she steps outside, her brain will be put into a physical state that it's never been in before, and as a result she will feel enlightened. This conclusion gives us no insight whatsoever into what exactly goes on during that state-change or why it's so special, which is why I think it's a stupid thought-experiment.
It isn't intended to answer your question about neuroscience.It is intended to pose the philosopher's question about the limitations of physicalism. If physicalism is limited, that eventually folds back to your question, since one way of explaining the limitation of physicalism is that there are non-physical things going on.
When she steps outside, something physical happens in her brain that has never happened before. Maybe something "non-physical" (huh?) also happens, maybe it doesn't. We have gained no insight.
If we agree that she learns something on stepping outside we have learnt that a version of physicalism is false.
Can you state what that version is? Whatever it is, it's nothing I subscribe to, and I call myself a physicalist.
There are broadly speaking two versions of physicalism: ontological physicalism, according to which everything that exists is material, spatio-temporal, etc; and epistemological physicalism, according to which everything can be explained in physical terms. Physicalism can be challenged by the inexplicability of qualia in two ways. Firstly, qualia might be physically inexplicable because they are not physical things, which contradicts ontological physicalim. Secondly, the phsyical inexplicability of qualia might be down to their having a first-person epistemology, which contradicts epistemological physicalism. Epistemological physicalism requires that eveything be explicable in physical terms, which implies that everything is explicable in objective, descriptive, public, third-person terms. If there are some things which can only be known by acquantance, subjectively, in first person terms, then it is not the case that everything can be explained in physicalese. However, ontological physicalism could still hold.
Or, you could notice that the apparent inexplicability of qualia is a sign that you are confused. ;-)
OK. You understand qualia, Please de-confuse me on the subject.
My conclusion in the Mary's room thought experiment doesn't challenge either of these versions: something new happens when she steps outside, and there's a perfectly good purely physical explanation of what and why. It is nothing more than an artifact of how human brains are built that Mary is unable to make the same physical thing happen, with the same result, without the assistance of either red light or appropriate surgical tools. A slightly more evolved Mary with a few extra neurons leading into her hippocampus would have no such difficulty.
Incidentally, while agreeing with your main point, I feel I ought to challenge the implications of "more evolved." This has nothing to do with Mary's position on some scale of evolution; she could be "less evolved" and have those neurons, or "more evolved" and lack them.
Mary still doesn't have to make anything special happen to her brain have knowledge of anything else. She can still understand photosynthesis without photosynthesising.