Semi relevant; I posted the following LWish thing in a discussion thread on a forum:

"we here have an enormous amount of extremely strong and general evidence that excludes huge areas of hypothesis space. This is the STRONGLY DOMINANT reason you shouldn't believe certain kinds of things even if someone you trust sincerely tells you to. Things like "physical laws don't have exceptions, no exceptions", "¨there are no irreducibly mental (=supernatural) phenomena", "Due to huge flaws in the way human brains work, billions of people CAN be wrong, and frequently are. You can't even trust your own brain.". We have no reason to believe Equestria and ponykind have similar overriding principles. "

(Please note that this was not written for LW, so therefore I were sloppy and also oversimplifying things due to inferential distance.)