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Regex comments on No, Seriously. Just Try It. - Less Wrong
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Great post. A useful followup might be "Just try what?", which would address how to generate and weigh ideas to be tested. Like you mention, scientifically established (or at least supported) ideas are usually the best starting point, but how do we fill in the gaps in this knowledge that you alluded to?
I mention this because there's no way "drink spoonfuls of vegetable oil" would have even occurred to me as a hypothesis, and if it had I would surely have laughed it away.
my answer to this question has become: 1) Research the topic 2) gather many ancedotes and strategies 3) try them 4) as my pool of suggested actions runs low, either brainstorm or go and gather more.