What scientism said is congruent with my experiences. I tried one time while being on the strongly-irrational/strongly-depressed-side to fight the irrationality. I refused the negative emotions to be accurate and trained myself to flag and consciouly counter all irrational thoughts with the accurate, positive thoughts. I described it then as a civil war inside my body. It was highly exhausting, my body and brain ached as if overworked, hands trembled, and I was highly agitated. I reported it then as a really good feeling, but the depression was lurking in the depths and attacking every few minutes or so with a "depressive" thought. It was like a two-day episode of being manic.

Since then I did not investigate its reproduceability, it was rather frightening, costed a lot of willpower and, luckily, I have not been so deep into depression again.