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gwern comments on Living Forever is Hard, or, The Gompertz Curve - Less Wrong
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I think he wants randomized controlled trials. Which of course no ethics board would ever approve because avoiding aspirin in kids is not that hard or expensive, and the cost of confirming it would be too high.
("You want to test whether slamming your face into the wall causes pain, and doesn't just correlate with it? Why on earth?")
We have a plausible mechanism (confirmed by massive amounts of science) by which slamming your face into the wall causes pain; for the link between Aspirin and Reye's syndrome there is no such plausible mechanism.