Also, DVORAK is strictly better than QWERTY, ignoring the inconvenience of being forced to switch back and forth between keysets.

Extra Datapoint: I've used Dvorak since I was 13. It took me maybe a week or two of using it to do my homework before I felt comfortable. Back in 1998, it was a pain in the ass for my family for the first few years because it was tricky to switch the computer back and forth, but this is a solved problem in modern OSs. The last time I experienced the slightest inconvenience from using Dvorak was 4 years ago when I was in college and using locked-down library computers.

Completely Anecdotal, Probably Worthless Datapoint: I program computers for a living. I have never experienced RSI.